Institut Curie


The web supplement to Fabien Reyal, Nicolas Stransky,
Isabelle Bernard-Pierrot et al.
Cancer Research, 2005, Vol. 65, Issue 4

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VISUALIZING CHROMOSOMES AS TRANSCRIPTOME CORRELATION MAPS: EVIDENCE OF CHROMOSOMAL DOMAINS CONTAINING COEXPRESSED GENES. A STUDY OF 130 INVASIVE DUCTAL BREAST CARCINOMAS
Fabien Reyal1,2*, Nicolas Stransky1*, Isabelle Bernard-Pierrot1*, Anne Vincent-Salomon3, Yann de Rycke4, Paul Elvin5, Andrew Cassidy5, Alexander Graham5, Carolyn Spraggon5, Yoann Désille1, Alain Fourquet6, Claude Nos2, Pierre Pouillart7, Henri Magdelenat8, Dominique Stoppa-Lyonnet3, Jérôme Couturier3, Brigitte Sigal-Zafrani3§, Bernard Asselain4, Xavier Sastre-Garau3, Olivier Delattre9, Jean Paul Thiery1,8, François Radvanyi1#
1 UMR 144, CNRS, Institut Curie, Paris, France
2 Department of Surgery, Institut Curie, Paris, France
3 Department of Tumor Biology, Institut Curie, Paris, France
4 Department of Biostatistics, Institut Curie, Paris, France
5 Astra Zeneca, Alderley Park, United Kingdom
6 Department of Radiotherapy, Institut Curie, Paris, France
7 Department of Medical Oncology, Institut Curie, Paris, France
8 Department of Translational Research, Institut Curie, Paris, France
9 U509, INSERM, Institut Curie, Paris, France

* these three authors contributed equally to this work
§ on behalf of the Institut Curie Breast Group

# correspondence should be addressed to François Radvanyi
This work was supported by the CNRS, the Institut Curie Breast Cancer program, the European FP5 IST HKIS project and Comité de Paris Ligue Nationale Contre le Cancer (Laboratoire associé). Dr F. Reyal and Dr I. Bernard-Pierrot were supported by fellowships from Ligue Nationale Contre le Cancer and N. Stransky by a fellowship from the French Ministry of Education and Research.

Figure 1:
Number of genes with a TC score above the threshold, as a function of the size of the moving window (2n).
Starting from 2n=20, the number of correlated genes reaches a plateau.
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Figure 2:
Transcription correlation map of 130 invasive ductal carcinomas of the breast, for chromosomes 1 to X.
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Figure 3:
Histogram of the gene densities among the genome (blue histogram bars), within 2 Mb slices. The histogram of the numbers of correlated genes (red bars) is superimposed to the gene densities and harbors a color shape proportional to the percentage of correlated genes among the total number of genes for each slice. It appears that highest percentages of genes presenting a significant correlation of expression with their neighbours, do not correspond to highest gene densities.
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Figure 4:
Chromosomal domains of coexpressed genes on chromosome 16.
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Original figures of the article
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Table 1 :
Clinical data of the 130 invasive ductal breast carcinomas.
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Table 2 :
Complete list of genes which TC score is above the threshold for the transcription correlation map of 130 invasive ductal breast carcinomas.
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Get it (csv format) (317Kb)
Last modified May 17 2005 10:57:57